The Complete Guide to GLP-1 Medications for Weight Los
Everything you need to know about GLP-1 medications, how they work, and what to expect from treatment.
What Are GLP-1 Medications?
GLP-1 (glucagon-like peptide-1) receptor agonists are a revolutionary class of medications that have transformed the treatment of obesity and type 2 diabetes. These medications work by mimicking the effects of a naturally occurring hormone that regulates appetite, blood sugar, and metabolism.
How Do They Work?
When you eat, your body releases GLP-1, which signals to your brain that you're full. GLP-1 medications enhance this natural process by:
- Slowing gastric emptying, keeping food in your stomach longer
- Reducing appetite and food cravings
- Improving insulin sensitivity and blood sugar control
- Potentially protecting cardiovascular health
Available GLP-1 Medications
The two most popular GLP-1 medications for weight loss are:
Semaglutide (Wegovy/Ozempic)
Semaglutide is a once-weekly injection that has shown average weight loss of 15-17% in clinical trials. Wegovy is the FDA-approved weight loss version, while Ozempic is approved for diabetes.
Tirzepatide (Zepbound/Mounjaro)
Tirzepatide is a dual GIP/GLP-1 agonist that has shown even greater weight loss results, with patients losing up to 22.5% of their body weight in trials.
What to Expect
Treatment typically starts at a low dose that gradually increases over several months. Most patients notice reduced appetite within the first few weeks. Common side effects include nausea, which usually improves as your body adjusts.