Semaglutide vs Tirzepatide: Which Is Right for You?
A detailed comparison of the two leading GLP-1 medications to help you make an informed decision.
The Two Giants of Weight Loss Medications
Semaglutide and tirzepatide represent the cutting edge of medical weight loss treatment. Both are highly effective, but they have important differences that may make one more suitable for your needs.
Mechanism of Action
Semaglutide
Semaglutide is a pure GLP-1 receptor agonist. It works by activating GLP-1 receptors in the brain and gut, reducing appetite and slowing digestion.
Tirzepatide
Tirzepatide is a "twincretin" that activates both GLP-1 and GIP receptors. This dual action may provide enhanced metabolic benefits and greater weight loss.
Clinical Trial Results
In head-to-head trials:
- Semaglutide users lost an average of 15-17% body weight
- Tirzepatide users lost an average of 20-22.5% body weight
Side Effect Profiles
Both medications share similar side effects, primarily gastrointestinal:
- Nausea (more common initially)
- Constipation or diarrhea
- Decreased appetite
Cost Considerations
Without insurance, both medications are expensive ($1,000+/month). However, compounded versions and telehealth programs offer more affordable alternatives starting around $199/month.